New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
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Using one-molecule optical and AFM imaging and pressure-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis pursuits include:
It was only while in the nineteen nineties however, when nanotechnology experienced Superior into a amount the place one molecules could possibly be manipulated, that the main experimental units commenced to appear.
‘It was basically a matter of selecting up a book on cell biology and beginning to read. I had originate from a world of ultra-significant vacuums, cryostats and quantum phenomena, and now I was Functioning at home temperature with molecular biology kits.
Given that 2000, Dekker has shifted the key target of his perform in direction of biophysics in which he scientific studies the Homes of single biomolecules and cells using the applications of nanotechnology. This alteration of industry was pushed by his fascination to the exceptional working of biological molecular buildings, together with with the very long-expression viewpoint that many interesting discoveries is usually predicted In this particular area.[5] Latest traces of study in his biophysics team are from the regions of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and to start with at any time review with the dynamics DNA supercoils and the invention of supercoil hopping
Direct immobilization of indigenous yeast iso-one cytochrome c on bare gold: speedy electron relay to redox enzymes and zeptomole protein-movie voltammetry
We use nanofabricated microfluidic buildings to pattern https://www.ceesdekker.net spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks which assess the fundamental purpose of spatial confinement in the molecular and cellular amount. Our projects incorporate the subsequent:
Nanopores depict a sublime and adaptable Software to measure solitary molecules. We exploration novel detection modes with reliable-state nanopores as well as a variety of ways to measure proteins with nanopores. Jobs encompass the following:
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Resolving the phase sizing in condensin-driven DNA loop extrusion identifies ATP binding given that the phase-building method
Example (4) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is shown in grey, the rim on the pore is highlighted in red, as well as a 3D rendering with the movement from the DNA rod is shown.
1999, 1st measurement with the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for just a new Luttinger description of interacting electrons in nanotubes
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent design in 2005. (nl)